β-Arrestin-Selective G Protein-Coupled Receptor Agonists Engender Unique Biological Efficacy in Vivo

Biased G protein-coupled receptor agonists are orthosteric ligands that possess pathway-selective efficacy, activating or inhibiting only a subset of the signaling repertoire of their cognate receptors. In vitro, d-Trp(12),Tyr(34)-bPTH(7–34) [bPTH(7–34)], a biased agonist for the type 1 PTH receptor...

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Detalhes bibliográficos
Main Authors: Gesty-Palmer, Diane, Yuan, Ling, Martin, Bronwen, Wood, William H., Lee, Mi-Hye, Janech, Michael G., Tsoi, Lam C., Zheng, W. Jim, Luttrell, Louis M., Maudsley, Stuart
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683806/
https://ncbi.nlm.nih.gov/pubmed/23315939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2012-1091
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