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The Origins of Diversity and Specificity in G Protein-Coupled Receptor Signaling

The modulation of transmembrane signaling by G protein-coupled receptors (GPCRs) constitutes the single most important therapeutic target in medicine. Drugs acting on GPCRs have traditionally been classified as agonists, partial agonists, or antagonists based on a two-state model of receptor functio...

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Bibliografiske detaljer
Main Authors: Maudsley, Stuart, Martin, Bronwen, Luttrell, Louis M.
Format: Artigo
Sprog:Inglês
Udgivet: 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2656918/
https://ncbi.nlm.nih.gov/pubmed/15805429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.105.083121
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