Activation of the Nucleotide Oligomerization Domain Signaling Pathway by the Non-bacterially Derived Xanthone Drug 5′6-Dimethylxanthenone-4-acetic Acid (Vadimezan)

The cytosolic nucleotide-binding oligomerization domain 1 (NOD1)/CARD4 and NOD2/CARD15 proteins are members of NOD-like receptors recognizing specific motifs within peptidoglycans of both Gram-negative and Gram-positive bacteria. NOD1 and NOD2 signal via the downstream adaptor serine/threonine kinas...

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Detalhes bibliográficos
Main Authors: Cheng, Guanjun, Sun, Jing, Fridlender, Zvi G., Wang, Liang-Chuan S., Ching, Lai-Ming, Albelda, Steven M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856263/
https://ncbi.nlm.nih.gov/pubmed/20118240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.065631
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