Blocking TGFβ via Inhibition of the αvβ6 Integrin: A Possible Therapy for Systemic Sclerosis Interstitial Lung Disease

Por Katsumoto, Tamiko R., Violette, Shelia M., Sheppard, Dean
Publicado em 2011

The Coagulation System Contributes to αVβ6 Integrin Expression and Liver Fibrosis Induced by Cholestasis

Por Sullivan, Bradley P., Weinreb, Paul H., Violette, Shelia M., Luyendyk, James P.
Publicado em 2010

Constitutively Activated Stat3 Induces Tumorigenesis and Enhances Cell Motility of Prostate Epithelial Cells through Integrin β6

Por Azare, Janeen, Leslie, Kenneth, Al-Ahmadie, Hikmat, Gerald, William, Weinreb, Paul H., Violette, Shelia M., Bromberg, Jacqueline
Publicado em 2007

Mice that lack activity of αvβ6- and αvβ8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null mice

Por Aluwihare, Poshala, Mu, Zhenyu, Zhao, Zhicheng, Yu, Dawen, Weinreb, Paul H., Horan, Gerald S., Violette, Shelia M., Munger, John S.
Publicado em 2009

α(v)β(6) Integrin Is Required for TGFβ1-Mediated Matrix Metalloproteinase2 Expression

Por Dutta, Anindita, Li, Jing, Fedele, Carmine, Sayeed, Aejaz, Singh, Amrita, Violette, Shelia M., Manes, Thomas D., Languino, Lucia R.
Publicado no Biochem J (2015)

Role of αvβ6 Integrin in Acute Biliary Fibrosis

Por Wang, Bruce, Dolinski, Brian M., Kikuchi, Noriko, Leone, Diane R., Peters, Marion G., Weinreb, Paul H., Violette, Shelia M., Bissell, D. Montgomery
Publicado em 2007

Lysophosphatidic Acid Increases Proximal Tubule Cell Secretion of Profibrotic Cytokines PDGF-B and CTGF through LPA2- and Gαq-Mediated Rho and αvβ6 Integrin-Dependent Activation of...

Por Geng, Hui, Lan, Rongpei, Singha, Prajjal K., Gilchrist, Annette, Weinreb, Paul H., Violette, Shelia M., Weinberg, Joel M., Saikumar, Pothana, Venkatachalam, Manjeri A.
Publicado em 2012

Lysophosphatidic Acid Induces αvβ6 Integrin-Mediated TGF-β Activation via the LPA2 Receptor and the Small G Protein Gα(q)

Por Xu, Ming Yan, Porte, Joanne, Knox, Alan J., Weinreb, Paul H., Maher, Toby M., Violette, Shelia M., McAnulty, Robin J., Sheppard, Dean, Jenkins, Gisli
Publicado em 2009

Inhibition of the α(v)β(6) integrin leads to limited alteration of TGF-α-induced pulmonary fibrosis

Por Madala, Satish K., Korfhagen, Thomas R., Schmidt, Stephanie, Davidson, Cynthia, Edukulla, Ramakrishna, Ikegami, Machiko, Violette, Shelia M., Weinreb, Paul H., Sheppard, Dean, Hardie, William D.
Publicado em 2014

Overexpression of Fibroblast Growth Factor-10 during Both Inflammatory and Fibrotic Phases Attenuates Bleomycin-induced Pulmonary Fibrosis in Mice

Por Gupte, Varsha V., Ramasamy, Suresh K., Reddy, Raghava, Lee, Jooeun, Weinreb, Paul H., Violette, Shelia M., Guenther, Andreas, Warburton, David, Driscoll, Barbara, Minoo, Parviz, Bellusci, Saverio
Publicado em 2009

Interleukin-1β Causes Acute Lung Injury via αvβ5 and αvβ6 Integrin–Dependent Mechanisms

Por Ganter, Michael T., Roux, Jérémie, Miyazawa, Byron, Howard, Marybeth, Frank, James A., Su, George, Sheppard, Dean, Violette, Shelia M., Weinreb, Paul H., Horan, Gerald S., Matthay, Michael A., Pittet, Jean-François
Publicado em 2008

Role of Integrin αvβ6 in Acute Lung Injury Induced by Pseudomonas aeruginosa

Por Song, Yuanlin, Pittet, Jean Francois, Huang, Xiaozhu, He, Hong, Lynch, Susan V., Violette, Shelia M., Weinreb, Paul H., Horan, Gerald S., Carmago, Amua, Sawa, Yoriko, Bernstein, Xin Liu, Wiener-Kronish, Jeanine P.
Publicado em 2008

Inhibition of integrin α(V)β(6) changes fibril thickness of stromal collagen in experimental carcinomas

Por Olof Olsson, P., Gustafsson, Renata, Salnikov, Alexei V., Göthe, Maria, Zeller, Kathrin S., Friman, Tomas, Baldetorp, Bo, Koopman, Louise A., Weinreb, Paul H., Violette, Shelia M., Kalamajski, Sebastian, Heldin, Nils-Erik, Rubin, Kristofer
Publicado no Cell Commun Signal (2018)

Amplification of TGFβ Induced ITGB6 Gene Transcription May Promote Pulmonary Fibrosis

Por Tatler, Amanda L., Goodwin, Amanda T., Gbolahan, Olumide, Saini, Gauri, Porte, Joanne, John, Alison E., Clifford, Rachel L., Violette, Shelia M., Weinreb, Paul H., Parfrey, Helen, Wolters, Paul J., Gauldie, Jack, Kolb, Martin, Jenkins, Gisli
Publicado no PLoS One (2016)

Uncoupling of the profibrotic and hemostatic effects of thrombin in lung fibrosis

Por Shea, Barry S., Probst, Clemens K., Brazee, Patricia L., Rotile, Nicholas J., Blasi, Francesco, Weinreb, Paul H., Black, Katharine E., Sosnovik, David E., Van Cott, Elizabeth M., Violette, Shelia M., Caravan, Peter, Tager, Andrew M.
Publicado no JCI Insight (2017)

The αvβ6 integrin in cancer cell-derived small extracellular vesicles enhances angiogenesis

Por Krishn, Shiv Ram, Salem, Israa, Quaglia, Fabio, Naranjo, Nicole M., Agarwal, Ekta, Liu, Qin, Sarker, Srawasti, Kopenhaver, Jessica, McCue, Peter A., Weinreb, Paul H., Violette, Shelia M., Altieri, Dario C., Languino, Lucia R.
Publicado no J Extracell Vesicles (2020)

Inhibition of Integrin αvβ6, an Activator of Latent Transforming Growth Factor-β, Prevents Radiation-induced Lung Fibrosis

Por Puthawala, Khalid, Hadjiangelis, Nicos, Jacoby, Steven C., Bayongan, Emmanuel, Zhao, Zhicheng, Yang, Zhiwei, Devitt, Mary Louise, Horan, Gerald S., Weinreb, Paul H., Lukashev, Matvey E., Violette, Shelia M., Grant, Kristen S., Colarossi, Cristina, Formenti, Silvia C., Munger, John S.
Publicado em 2008

Connective Tissue Growth Factor and Integrin αvβ6: a New Pair of Regulators Critical for Ductular Reaction and Biliary Fibrosis

Por Pi, Liya, Robinson, Paulette M., Jorgensen, Marda, Oh, Seh-Hoon, Brown, Alicia R., Weinreb, Paul H., Trinh, Thu Le, Yianni, Protopapadakis, Liu, Chen, Leask, Andrew, Violette, Shelia M., Scott, Edward W., Schultz, Gregory S., Petersen, Bryon E.
Publicado no Hepatology (2015)

The αvβ6 integrin promotes an osteolytic program through upregulation of MMP2

Por Dutta, Anindita, Li, Jing, Lu, Huimin, Akech, Jacqueline, Pratap, Jitesh, Wang, Tao, Zerlanko, Brad J., FitzGerald, Thomas J., Jiang, Zhong, Birbe, Ruth, Wixted, John, Violette, Shelia M., Stein, Janet L., Stein, Gary S., Lian, Jane B., Languino, Lucia R.
Publicado em 2014

Type I collagen-targeted PET probe for pulmonary fibrosis detection and staging in preclinical models

Por Désogère, Pauline, Tapias, Luis F., Hariri, Lida P., Rotile, Nicholas J., Rietz, Tyson A., Probst, Clemens K., Blasi, Francesco, Day, Helen, Mino-Kenudson, Mari, Weinreb, Paul, Violette, Shelia M., Fuchs, Bryan C., Tager, Andrew M., Lanuti, Michael, Caravan, Peter
Publicado no Sci Transl Med (2017)