The αvβ6 integrin promotes an osteolytic program through upregulation of MMP2

The molecular circuitries controlling osseous prostate metastasis are known to depend on the activity of multiple pathways, including integrin signaling. Here, we demonstrate that the αvβ6 integrin is upregulated in human prostate cancer bone metastasis. In prostate cancer cells, this integrin is a...

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Detalhes bibliográficos
Main Authors: Dutta, Anindita, Li, Jing, Lu, Huimin, Akech, Jacqueline, Pratap, Jitesh, Wang, Tao, Zerlanko, Brad J., FitzGerald, Thomas J., Jiang, Zhong, Birbe, Ruth, Wixted, John, Violette, Shelia M., Stein, Janet L., Stein, Gary S., Lian, Jane B., Languino, Lucia R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3967411/
https://ncbi.nlm.nih.gov/pubmed/24385215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-1796
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