α(v)β(6) Integrin Promotes Castrate-Resistant Prostate Cancer Through JNK1-Mediated Activation of Androgen Receptor

Androgen receptor signaling fuels prostate cancer and is a major therapeutic target. However, mechanisms of resistance to therapeutic androgen ablation are not well understood. Here, using a prostate cancer mouse model, Pten(pc−/−), carrying a prostate epithelial-specific Pten deletion, we show that...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Lu, Huimin, Wang, Tao, Li, Jing, Fedele, Carmine, Liu, Qin, Zhang, Jianzhong, Jiang, Zhong, Jain, Dhanpat, Iozzo, Renato V., Violette, Shelia M., Weinreb, Paul H., Davis, Roger J., Gioeli, Daniel, FitzGerald, Thomas J., Altieri, Dario C., Languino, Lucia R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012867/
https://ncbi.nlm.nih.gov/pubmed/27450452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-0543
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