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Exosome-mediated Transfer of α(v)β(3) Integrin from Tumorigenic to Non-Tumorigenic Cells Promotes a Migratory Phenotype

The α(v)β(3) integrin is known to be highly up-regulated during cancer progression and promotes a migratory and metastatic phenotype in many types of tumors. We hypothesized that the α(v)β(3) integrin is transferred through exosomes and, upon transfer, has the ability to support functional aberratio...

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Detalhes bibliográficos
Publicado no:Mol Cancer Res
Main Authors: Singh, Amrita, Fedele, Carmine, Lu, Huimin, Nevalainen, Marja T., Keen, James H., Languino, Lucia R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5107121/
https://ncbi.nlm.nih.gov/pubmed/27439335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-16-0058
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