Prostate cancer sheds the αvβ3 integrin in vivo through exosomes

The αvβ3 integrin has been shown to promote aggressive phenotypes in many types of cancers, including prostate cancer. We show that GFP-labeled αvβ3 derived from cancer cells circulates in the blood and is detected in distant lesions in NOD scid gamma (NSG) mice. We, therefore, hypothesized that αvβ...

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Dettagli Bibliografici
Pubblicato in:Matrix Biol
Autori principali: Krishn, Shiv Ram, Singh, Amrita, Bowler, Nicholas, Duffy, Alexander N., Friedman, Andrea, Fedele, Carmine, Kurtoglu, Senem, Tripathi, Sushil K., Wang, Kerith, Hawkins, Adam, Sayeed, Aejaz, Goswami, Chirayu P., Thakur, Madhukar L., Iozzo, Renato V., Peiper, Stephen C., Kelly, William K., Languino, Lucia R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6541230/
https://ncbi.nlm.nih.gov/pubmed/30098419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.matbio.2018.08.004
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