Lysophosphatidic Acid Induces αvβ6 Integrin-Mediated TGF-β Activation via the LPA2 Receptor and the Small G Protein Gα(q)

Activation of latent transforming growth factor β (TGF-β) by αvβ6 integrin is critical in the pathogenesis of lung injury and fibrosis. We have previously demonstrated that the stimulation of protease activated receptor 1 promotes αvβ6 integrin-mediated TGF-β activation via RhoA, which is known to m...

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Detalhes bibliográficos
Main Authors: Xu, Ming Yan, Porte, Joanne, Knox, Alan J., Weinreb, Paul H., Maher, Toby M., Violette, Shelia M., McAnulty, Robin J., Sheppard, Dean, Jenkins, Gisli
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2009
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671359/
https://ncbi.nlm.nih.gov/pubmed/19147812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080160
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