Lysophosphatidic Acid Increases Proximal Tubule Cell Secretion of Profibrotic Cytokines PDGF-B and CTGF through LPA2- and Gαq-Mediated Rho and αvβ6 Integrin-Dependent Activation of TGF-β

After ischemia-reperfusion injury (IRI), kidney tubules show activated transforming growth factor β (TGF-β) signaling and increased expression of profibrotic peptides, platelet-derived growth factor-B (PDGF-B) and connective tissue growth factor (CTGF). If tubule repair after IRI is incomplete, sust...

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Detalhes bibliográficos
Main Authors: Geng, Hui, Lan, Rongpei, Singha, Prajjal K., Gilchrist, Annette, Weinreb, Paul H., Violette, Shelia M., Weinberg, Joel M., Saikumar, Pothana, Venkatachalam, Manjeri A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2012
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463629/
https://ncbi.nlm.nih.gov/pubmed/22885106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2012.06.035
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