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Proximal tubule LPA1 and LPA2 receptors use divergent signaling pathways to additively increase profibrotic cytokine secretion

Lysophosphatidic acid (LPA) increases platelet-derived growth factor-B (PDGFB) and connective tissue growth factor (CTGF) production and secretion by proximal tubule (PT) cells through LPA2 receptor-G(q)α-α(v)β(6)-integrin-mediated activation of transforming growth factor-β1 (TGFB1). LPA2, β(6)-inte...

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Detalhes bibliográficos
Publicado no:Am J Physiol Renal Physiol
Main Authors: Geng, Hui, Lan, Rongpei, Liu, Yaguang, Chen, Wei, Wu, Meng, Saikumar, Pothana, Weinberg, Joel M., Venkatachalam, Manjeri A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7988817/
https://ncbi.nlm.nih.gov/pubmed/33427061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00494.2020
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