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Proximal tubule LPA1 and LPA2 receptors use divergent signaling pathways to additively increase profibrotic cytokine secretion
Lysophosphatidic acid (LPA) increases platelet-derived growth factor-B (PDGFB) and connective tissue growth factor (CTGF) production and secretion by proximal tubule (PT) cells through LPA2 receptor-G(q)α-α(v)β(6)-integrin-mediated activation of transforming growth factor-β1 (TGFB1). LPA2, β(6)-inte...
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| Udgivet i: | Am J Physiol Renal Physiol |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Physiological Society
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7988817/ https://ncbi.nlm.nih.gov/pubmed/33427061 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00494.2020 |
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