Anaerobic and aerobic pathways for salvage of proximal tubules from hypoxia-induced mitochondrial injury

We have further examined the mechanisms for a severe mitochondrial energetic deficit, deenergization, and impaired respiration in complex I that develop in kidney proximal tubules during hypoxia-reoxygenation, and their prevention and reversal by supplementation with α-ketoglutarate (α-KG) + asparta...

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Main Authors: WEINBERG, JOEL M., VENKATACHALAM, MANJERI A., ROESER, NANCY F., SAIKUMAR, POTHANA, DONG, ZHENG, SENTER, RUTH A., NISSIM, ITZHAK
Format: Artigo
Sprog:Inglês
Udgivet: 2000
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2854567/
https://ncbi.nlm.nih.gov/pubmed/11053054
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