TGF-β induced TMEPAI/PMEPA1 inhibits canonical Smad signaling through R-Smad sequestration and promotes non-canonical PI3K/Akt signaling by reducing PTEN in triple negative breast cancer

TMEPAI (transmembrane prostate androgen-induced) is amplified at genomic, transcript and protein levels in triple-negative breast cancers and promotes TGF-β dependent growth, motility and invasion. Tumor promotion by TMEPAI depends on two different but related actions on TGF-β signaling. Firstly, TM...

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Detalhes bibliográficos
Main Authors: Singha, Prajjal K., Pandeswara, Srilakshmi, Geng, Hui, Lan, Rongpei, Venkatachalam, Manjeri A., Saikumar, Pothana
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4209604/
https://ncbi.nlm.nih.gov/pubmed/25352949
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