PTEN loss defines a TGF-β-induced tubule phenotype of failed differentiation and JNK signaling during renal fibrosis

We investigated the signaling basis for tubule pathology during fibrosis after renal injury. Numerous signaling pathways are activated physiologically to direct tubule regeneration after acute kidney injury (AKI) but several persist pathologically after repair. Among these, transforming growth facto...

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Main Authors: Lan, Rongpei, Geng, Hui, Polichnowski, Aaron J., Singha, Prajjal K., Saikumar, Pothana, McEwen, Donald G., Griffin, Karen A., Koesters, Robert, Weinberg, Joel M., Bidani, Anil K., Kriz, Wilhelm, Venkatachalam, Manjeri A.
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2012
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362177/
https://ncbi.nlm.nih.gov/pubmed/22301622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00660.2011
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