Mitochondrial Remodeling Following Fission Inhibition by 15d-PGJ2 Involves Molecular Changes in Mitochondrial Fusion Protein OPA1

We showed earlier that 15 deoxy Δ(12, 14) prostaglandin J2 (15d-PGJ2) inactivates Drp1 and induces mitochondrial fusion [1]. However, prolonged incubation of cells with 15d-PGJ2 resulted in remodeling of fused mitochondria into large swollen mitochondria with irregular cristae structure. While initi...

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Huvudupphovsmän: Kar, Rekha, Mishra, Nandita, Singha, Prajjal K., Venkatachalam, Manjeri A., Saikumar, Pothana
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2942079/
https://ncbi.nlm.nih.gov/pubmed/20678484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2010.07.108
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