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Lysophosphatidic Acid Increases Proximal Tubule Cell Secretion of Profibrotic Cytokines PDGF-B and CTGF through LPA2- and Gαq-Mediated Rho and αvβ6 Integrin-Dependent Activation of TGF-β
After ischemia-reperfusion injury (IRI), kidney tubules show activated transforming growth factor β (TGF-β) signaling and increased expression of profibrotic peptides, platelet-derived growth factor-B (PDGF-B) and connective tissue growth factor (CTGF). If tubule repair after IRI is incomplete, sust...
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Główni autorzy: | , , , , , , , , |
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Format: | Artigo |
Język: | Inglês |
Wydane: |
American Society for Investigative Pathology
2012
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Hasła przedmiotowe: | |
Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3463629/ https://ncbi.nlm.nih.gov/pubmed/22885106 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2012.06.035 |
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