Amplification of TGFβ Induced ITGB6 Gene Transcription May Promote Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) is a devastating, progressive disease with poor survival rates and limited treatment options. Upregulation of αvβ6 integrins within the alveolar epithelial cells is a characteristic feature of IPF and correlates with poor patient survival. The pro-fibrotic cytokin...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Tatler, Amanda L., Goodwin, Amanda T., Gbolahan, Olumide, Saini, Gauri, Porte, Joanne, John, Alison E., Clifford, Rachel L., Violette, Shelia M., Weinreb, Paul H., Parfrey, Helen, Wolters, Paul J., Gauldie, Jack, Kolb, Martin, Jenkins, Gisli
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2016
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4975449/
https://ncbi.nlm.nih.gov/pubmed/27494713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0158047
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