Amplification of TGFβ Induced ITGB6 Gene Transcription May Promote Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) is a devastating, progressive disease with poor survival rates and limited treatment options. Upregulation of αvβ6 integrins within the alveolar epithelial cells is a characteristic feature of IPF and correlates with poor patient survival. The pro-fibrotic cytokin...

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Dades bibliogràfiques
Publicat a:PLoS One
Autors principals: Tatler, Amanda L., Goodwin, Amanda T., Gbolahan, Olumide, Saini, Gauri, Porte, Joanne, John, Alison E., Clifford, Rachel L., Violette, Shelia M., Weinreb, Paul H., Parfrey, Helen, Wolters, Paul J., Gauldie, Jack, Kolb, Martin, Jenkins, Gisli
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4975449/
https://ncbi.nlm.nih.gov/pubmed/27494713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0158047
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