Reduced Ets Domain-containing Protein Elk1 Promotes Pulmonary Fibrosis via Increased Integrin αvβ6 Expression

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with high mortality. Active TGFβ1 is considered central to the pathogenesis of IPF. A major mechanism of TGFβ1 activation in the lung involves the epithelially restricted αvβ6 integrin. Expression of the αvβ6 integrin is dram...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Tatler, Amanda L., Habgood, Anthony, Porte, Joanne, John, Alison E., Stavrou, Anastasios, Hodge, Emily, Kerama-Likoko, Cheryl, Violette, Shelia M., Weinreb, Paul H., Knox, Alan J., Laurent, Geoffrey, Parfrey, Helen, Wolters, Paul John, Wallace, William, Alberti, Siegfried, Nordheim, Alfred, Jenkins, Gisli
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4850293/
https://ncbi.nlm.nih.gov/pubmed/26861876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.692368
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