Deleterious Effects of Amyloid β Oligomers Acting as an Extracellular Scaffold for mGluR5

por Renner, Marianne, Lacor, Pascale N., Velasco, Pauline T., Xu, Jian, Contractor, Anis, Klein, William L., Triller, Antoine
Publicado 2010

Soluble state high resolution atomic force microscopy study of Alzheimer’s β-amyloid oligomers

por Shekhawat, Gajendra S., Lambert, Mary P., Sharma, Saurabh, Velasco, Pauline T., Viola, Kirsten L., Klein, William L., Dravid, Vinayak P.
Publicado 2009

Alzheimer’s-associated Aβ oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal

por Pitt, Jason, Roth, William, Lacor, Pascale, Blankenship, Matthew, Velasco, Pauline, De Felice, Fernanda, Breslin, Paul, Klein, William L.
Publicado 2009

Detection and Identification of Bioanalytes with High Resolution LSPR Spectroscopy and MALDI Mass Spectrometry

por Anker, Jeffrey N., Hall, W. Paige, Lambert, Mary P., Velasco, Pauline T., Mrksich, Milan, Klein, William L., Van Duyne, Richard P.
Publicado 2009

Brain Transit and Ameliorative Effects of Intranasally Delivered Anti-Amyloid-β Oligomer Antibody in 5XFAD Mice

por Xiao, Chun, Davis, Francesca J., Chauhan, Balwantsinh C., Viola, Kirsten L., Lacor, Pascale N., Velasco, Pauline T., Klein, William L., Chauhan, Neelima B.
Publicado 2013

Aβ Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

por Lacor, Pascale N., Buniel, Maria C., Furlow, Paul W., Sanz Clemente, Antonio, Velasco, Pauline T., Wood, Margaret, Viola, Kirsten L., Klein, William L.
Publicado en J Neurosci (2007)

Modulation of Amyloid-β Aggregation by Histidine-coordinating Cobalt(III) Schiff Base Complexes

por Heffern, Marie C., Velasco, Pauline T., Matosziuk, Lauren M., Coomes, Joseph L., Karras, Constantine, Ratner, Mark A., Klein, William B., Eckermann, Amanda L., Meade, Thomas J.
Publicado 2014

Elucidating Molecular Mass and Shape of a Neurotoxic Aβ Oligomer

por Sebollela, Adriano, Mustata, Gina-Mirela, Luo, Kevin, Velasco, Pauline T., Viola, Kirsten L., Cline, Erika N., Shekhawat, Gajendra S., Wilcox, Kyle C., Dravid, Vinayak P., Klein, William L.
Publicado en ACS Chem Neurosci (2014)

Nanoscale Synaptic Membrane Mimetic Allows Unbiased High Throughput Screen That Targets Binding Sites for Alzheimer’s-Associated Aβ Oligomers

por Wilcox, Kyle C., Marunde, Matthew R., Das, Aditi, Velasco, Pauline T., Kuhns, Benjamin D., Marty, Michael T., Jiang, Haoming, Luan, Chi-Hao, Sligar, Stephen G., Klein, William L.
Publicado en PLoS One (2015)

Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

por De Felice, Fernanda G., Vieira, Marcelo N. N., Bomfim, Theresa R., Decker, Helena, Velasco, Pauline T., Lambert, Mary P., Viola, Kirsten L., Zhao, Wei-Qin, Ferreira, Sergio T., Klein, William L.
Publicado 2009

Correction: A glycine zipper motif mediates the formation of toxic beta-amyloid oligomers in vitro and in vivo

por Fonte, Virginia, Dostal, Vishantie, Roberts, Christine M, Gonzales, Patrick, Lacor, Pascale N, Velasco, Pauline T, Magrane, Jordi, Dingwell, Natalie, Fan, Emily Y, Silverman, Michael A, Stein, Gretchen H, Link, Christopher D
Publicado 2014

Synapse-Binding Subpopulations of Aβ Oligomers Sensitive to Peptide Assembly Blockers and scFv Antibodies

por Velasco, Pauline T., Heffern, Marie C., Sebollela, Adriano, Popova, Izolda A., Lacor, Pascale N., Lee, Kevin B., Sun, Xiaoxia, Tiano, Benjamin N., Viola, Kirsten L., Eckermann, Amanda L., Meade, Thomas J., Klein, William L.
Publicado 2012

Alzheimer’s Toxic Amyloid Beta Oligomers: Unwelcome Visitors to the Na/K ATPase alpha3 Docking Station

por DiChiara, Thomas, DiNunno, Nadia, Clark, Jeffrey, Bu, Riana Lo, Cline, Erika N., Rollins, Madeline G., Gong, Yuesong, Brody, David L., Sligar, Stephen G., Velasco, Pauline T., Viola, Kirsten L., Klein, William L.
Publicado en Yale J Biol Med (2017)

Synaptic Targeting by Alzheimer's-Related Amyloid β Oligomers

por Lacor, Pascale N., Buniel, Maria C., Chang, Lei, Fernandez, Sara J., Gong, Yuesong, Viola, Kirsten L., Lambert, Mary P., Velasco, Pauline T., Bigio, Eileen H., Finch, Caleb E., Krafft, Grant A., Klein, William L.
Publicado en J Neurosci (2004)

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers

por De Felice, Fernanda G., Wu, Diana, Lambert, Mary P., Fernandez, Sara J., Velasco, Pauline T., Lacor, Pascale N., Bigio, Eileen H., Jerecic, Jasna, Acton, Paul J., Shughrue, Paul J., Chen-Dodson, Elizabeth, Kinney, Gene G., Klein, William L.
Publicado 2007

Towards Non-Invasive Diagnostic Imaging of Early-Stage Alzheimer’s Disease

por Viola, Kirsten L., Sbarboro, James, Sureka, Ruchi, De, Mrinmoy, Bicca, Maíra A., Wang, Jane, Vasavada, Shaleen, Satpathy, Sreyesh, Wu, Summer, Joshi, Hrushikesh, Velasco, Pauline T., MacRenaris, Keith, Waters, E. Alex, Lu, Chang, Phan, Joseph, Lacor, Pascale, Prasad, Pottumarthi, Dravid, Vinayak P., Klein, William L.
Publicado en Nat Nanotechnol (2014)

A human scFv antibody that targets and neutralizes high molecular weight pathogenic amyloid-β oligomers

por Sebollela, Adriano, Cline, Erika N., Popova, Izolda, Luo, Kevin, Sun, Xiaoxia, Ahn, Jay, Barcelos, Milena A., Bezerra, Vanessa N., Lyra e Silva, Natalia M., Patel, Jason, Pinheiro, Nathalia R., Qin, Lei A., Kamel, Josette M., Weng, Anthea, DiNunno, Nadia, Bebenek, Adrian M., Velasco, Pauline T., Viola, Kirsten L., Lacor, Pascale N., Ferreira, Sergio T., Klein, William L.
Publicado en J Neurochem (2017)