Brain Transit and Ameliorative Effects of Intranasally Delivered Anti-Amyloid-β Oligomer Antibody in 5XFAD Mice

Alzheimer’s disease (AD) is a global health crisis with limited treatment options. Despite major advances in neurotherapeutics, poor brain penetration due to the blood-brain barrier continues to pose a big challenge in overcoming the access of therapeutics to the central nervous system. In that rega...

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Main Authors: Xiao, Chun, Davis, Francesca J., Chauhan, Balwantsinh C., Viola, Kirsten L., Lacor, Pascale N., Velasco, Pauline T., Klein, William L., Chauhan, Neelima B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3722071/
https://ncbi.nlm.nih.gov/pubmed/23542865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-122419
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