Alzheimer’s-associated Aβ oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal

It now appears likely that soluble oligomers of amyloid-β(1-42) peptide, rather than insoluble fibrils, act as the primary neurotoxin in Alzheimer’s disease (AD). Consequently, compounds capable of altering the assembly state of these oligomers (referred to as ADDLs) may have potential for AD therap...

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Detalhes bibliográficos
Main Authors: Pitt, Jason, Roth, William, Lacor, Pascale, Blankenship, Matthew, Velasco, Pauline, De Felice, Fernanda, Breslin, Paul, Klein, William L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808212/
https://ncbi.nlm.nih.gov/pubmed/19631677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2009.07.018
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