Aβ Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

The basis for memory loss in early Alzheimer's disease (AD) seems likely to involve synaptic damage caused by soluble Aβ-derived oligomers (ADDLs). ADDLs have been shown to build up in the brain and CSF of AD patients and are known to interfere with mechanisms of synaptic plasticity, acting as...

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Publicat a:J Neurosci
Autors principals: Lacor, Pascale N., Buniel, Maria C., Furlow, Paul W., Sanz Clemente, Antonio, Velasco, Pauline T., Wood, Margaret, Viola, Kirsten L., Klein, William L.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2007
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672917/
https://ncbi.nlm.nih.gov/pubmed/17251419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3501-06.2007
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