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Modulation of Amyloid-β Aggregation by Histidine-coordinating Cobalt(III) Schiff Base Complexes
Oligomers of the Aβ42 peptide are significant neurotoxins linked to Alzheimer’s Disease (AD). Histidine (His) residues present at the N-terminus of Aβ42 are believed to influence toxicity by either serving as metal-ion binding sites (that promote oligomerization and oxidative damage) or facilitating...
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Main Authors: | , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2014
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4166533/ https://ncbi.nlm.nih.gov/pubmed/24961930 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201402201 |
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