Modulation of Amyloid-β Aggregation by Histidine-coordinating Cobalt(III) Schiff Base Complexes

Oligomers of the Aβ42 peptide are significant neurotoxins linked to Alzheimer’s Disease (AD). Histidine (His) residues present at the N-terminus of Aβ42 are believed to influence toxicity by either serving as metal-ion binding sites (that promote oligomerization and oxidative damage) or facilitating...

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Main Authors: Heffern, Marie C., Velasco, Pauline T., Matosziuk, Lauren M., Coomes, Joseph L., Karras, Constantine, Ratner, Mark A., Klein, William B., Eckermann, Amanda L., Meade, Thomas J.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4166533/
https://ncbi.nlm.nih.gov/pubmed/24961930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201402201
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