Epigenome‐wide association studies in Alzheimer’s disease; achievements and challenges

by van den Hove, Daniel L. A., Riemens, Renzo J. M., Koulousakis, Philippos, Pishva, Ehsan
Published in Brain Pathol (2020)

Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression

by Levy, Marion J. F., Boulle, Fabien, Steinbusch, Harry W., van den Hove, Daniël L. A., Kenis, Gunter, Lanfumey, Laurence
Published in Psychopharmacology (Berl) (2018)

Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage

by Bustelo, Martín, Barkhuizen, Melinda, van den Hove, Daniel L. A., Steinbusch, Harry Wilhelm. M., Bruno, Martín A., Loidl, C. Fabián, Gavilanes, Antonio W. Danilo
Published in Front Neurol (2020)

5-HTT independent effects of fluoxetine on neuroplasticity

by Levy, Marion J. F., Boulle, Fabien, Emerit, Michel Boris, Poilbout, Corinne, Steinbusch, Harry W. M., Van den Hove, Daniel L. A., Kenis, Gunter, Lanfumey, Laurence
Published in Sci Rep (2019)

Age-related epigenetic changes in hippocampal subregions of four animal models of Alzheimer’s disease

by Lardenoije, Roy, van den Hove, Daniël L.A., Havermans, Monique, van Casteren, Anne, Le, Kevin X., Palmour, Roberta, Lemere, Cynthia A., Rutten, Bart P.F.
Published in Mol Cell Neurosci (2017)

DNA methyltransferase isoforms expression in the temporal lobe of epilepsy patients with a history of febrile seizures

by de Nijs, Laurence, Choe, Kyonghwan, Steinbusch, Hellen, Schijns, Olaf E. M. G., Dings, Jim, van den Hove, Daniel L. A., Rutten, Bart P. F., Hoogland, Govert
Published in Clin Epigenetics (2019)

Effects of prenatal Poly I:C exposure on global histone deacetylase (HDAC) and DNA methyltransferase (DNMT) activity in the mouse brain

by Pujol Lopez, Yara, Kenis, Gunter, Stettinger, Waldtraud, Neumeier, Karin, de Jonge, Sylvia, Steinbusch, Harry W. M., Zill, Peter, van den Hove, Daniel L. A., Myint, Aye M.
Published in Mol Biol Rep (2016)

Prevention of age-related changes in hippocampal levels of 5-methylcytidine by caloric restriction

by Chouliaras, Leonidas, van den Hove, Daniel L.A., Kenis, Gunter, Keitel, Stella, Hof, Patrick R., van Os, Jim, Steinbusch, Harry W.M., Schmitz, Christoph, Rutten, Bart P.F.
Published 2011

Age-related increase in levels of 5-hydroxymethylcytosine in mouse hippocampus is prevented by caloric restriction

by Chouliaras, Leonidas, van den Hove, Daniel L.A., Kenis, Gunter, Keitel, Stella, Hof, Patrick R., van Os, Jim, Steinbusch, Harry W.M., Schmitz, Christoph, Rutten, Bart P.F.
Published 2012

Histone Deacetylase 2 in the Mouse Hippocampus: Attenuation of Age-Related Increase by Caloric Restriction

by Chouliaras, Leonidas, van den Hove, Daniel L.A., Kenis, Gunter, van Draanen, Michael, Hof, Patrick R., van Os, Jim, Steinbusch, Harry W.M., Schmitz, Christoph, Rutten, Bart P.F.
Published 2013

Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer’s disease patients

by Chouliaras, Leonidas, Mastroeni, Diego, Delvaux, Elaine, Grover, Andrew, Kenis, Gunter, Hof, Patrick R., Steinbusch, Harry W.M., Coleman, Paul D., Rutten, Bart P.F., van den Hove, Daniel L.A.
Published 2013

Age-related Disturbances in DNA (hydroxy)methylation in APP/PS1 Mice

by Chouliaras, Leonidas, Lardenoije, Roy, Kenis, Gunter, Mastroeni, Diego, Hof, Patrick R., van Os, Jim, Steinbusch, Harry W.M., van Leeuwen, Fred W., Rutten, Bart P.F., van den Hove, Daniel L.A.
Published in Transl Neurosci (2018)

The epigenetics of aging and neurodegeneration

by Lardenoije, Roy, Iatrou, Artemis, Kenis, Gunter, Kompotis, Konstantinos, Steinbusch, Harry W.M., Mastroeni, Diego, Coleman, Paul, Lemere, Cynthia A., Hof, Patrick R., van den Hove, Daniel L.A., Rutten, Bart P.F.
Published in Prog Neurobiol (2015)

Identification of Cholecystokinin by Genome-Wide Profiling as Potential Mediator of Serotonin-Dependent Behavioral Effects of Maternal Separation in the Amygdala

by Weidner, Magdalena T., Lardenoije, Roy, Eijssen, Lars, Mogavero, Floriana, De Groodt, Lilian P. M. T., Popp, Sandy, Palme, Rupert, Förstner, Konrad U., Strekalova, Tatyana, Steinbusch, Harry W. M., Schmitt-Böhrer, Angelika G., Glennon, Jeffrey C., Waider, Jonas, van den Hove, Daniel L. A., Lesch, Klaus-Peter
Published in Front Neurosci (2019)

An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene

by Roubroeks, Janou A.Y., Smith, Adam R., Smith, Rebecca G., Pishva, Ehsan, Ibrahim, Zina, Sattlecker, Martina, Hannon, Eilis J., Kłoszewska, Iwona, Mecocci, Patrizia, Soininen, Hilkka, Tsolaki, Magda, Vellas, Bruno, Wahlund, Lars-Olof, Aarsland, Dag, Proitsi, Petroula, Hodges, Angela, Lovestone, Simon, Newhouse, Stephen J., Dobson, Richard J.B., Mill, Jonathan, van den Hove, Daniël L.A., Lunnon, Katie
Published in Neurobiol Aging (2020)

CERT(L) reduces C16 ceramide, amyloid-β levels, and inflammation in a model of Alzheimer’s disease

by Crivelli, Simone M., Luo, Qian, Stevens, Jo A.A., Giovagnoni, Caterina, van Kruining, Daan, Bode, Gerard, den Hoedt, Sandra, Hobo, Barbara, Scheithauer, Anna-Lena, Walter, Jochen, Mulder, Monique T., Exley, Christopher, Mold, Matthew, Mielke, Michelle M., De Vries, Helga E., Wouters, Kristiaan, van den Hove, Daniel L. A., Berkes, Dusan, Ledesma, María Dolores, Verhaagen, Joost, Losen, Mario, Bieberich, Erhard, Martinez-Martinez, Pilar
Published in Alzheimers Res Ther (2021)

A meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights novel differentially methylated loci across cortex

by Smith, Rebecca G., Pishva, Ehsan, Shireby, Gemma, Smith, Adam R., Roubroeks, Janou A. Y., Hannon, Eilis, Wheildon, Gregory, Mastroeni, Diego, Gasparoni, Gilles, Riemenschneider, Matthias, Giese, Armin, Sharp, Andrew J., Schalkwyk, Leonard, Haroutunian, Vahram, Viechtbauer, Wolfgang, van den Hove, Daniel L. A., Weedon, Michael, Brokaw, Danielle, Francis, Paul T., Thomas, Alan J., Love, Seth, Morgan, Kevin, Walter, Jörn, Coleman, Paul D., Bennett, David A., De Jager, Philip L., Mill, Jonathan, Lunnon, Katie
Published in Nat Commun (2021)

Alzheimer’s disease-associated (hydroxy)methylomic changes in the brain and blood

by Lardenoije, Roy, Roubroeks, Janou A. Y., Pishva, Ehsan, Leber, Markus, Wagner, Holger, Iatrou, Artemis, Smith, Adam R., Smith, Rebecca G., Eijssen, Lars M. T., Kleineidam, Luca, Kawalia, Amit, Hoffmann, Per, Luck, Tobias, Riedel-Heller, Steffi, Jessen, Frank, Maier, Wolfgang, Wagner, Michael, Hurlemann, René, Kenis, Gunter, Ali, Muhammad, del Sol, Antonio, Mastroeni, Diego, Delvaux, Elaine, Coleman, Paul D., Mill, Jonathan, Rutten, Bart P. F., Lunnon, Katie, Ramirez, Alfredo, van den Hove, Daniël L. A.
Published in Clin Epigenetics (2019)