Misframed ubiquitin and impaired protein quality control: an early event in Alzheimer’s disease

Por Gentier, Romina J., van Leeuwen, Fred W.
Publicado no Front Mol Neurosci (2015)

Editorial: Ubiquitin and the Brain: Roles of Proteolysis in the Normal and Abnormal Nervous System

Por Hegde, Ashok N., van Leeuwen, Fred W.
Publicado no Front Mol Neurosci (2017)

Commentary: The landscape of transcription errors in eukaryotic cells

Por Verheijen, Bert M., van Leeuwen, Fred W.
Publicado no Front Genet (2017)

Deposition of mutant ubiquitin in parkinsonism–dementia complex of Guam

Por Verheijen, Bert M., Hashimoto, Tomoyo, Oyanagi, Kiyomitsu, van Leeuwen, Fred W.
Publicado no Acta Neuropathol Commun (2017)

Ubiquitin over-expression phenotypes and ubiquitin gene molecular misreading during aging in Drosophila melanogaster

Por Hoe, Nicholas, Huang, Chung M., Landis, Gary, Verhage, Marian, Ford, Daniel, Yang, Junsheng, van Leeuwen, Fred W., Tower, John
Publicado em 2011

Selective Transgenic Expression of Mutant Ubiquitin in Purkinje Cell Stripes in the Cerebellum

Por Verheijen, Bert M., Gentier, Romina J. G., Hermes, Denise J. H. P., van Leeuwen, Fred W., Hopkins, David A.
Publicado no Cerebellum (2016)

Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation

Por Lindsten, Kristina, de Vrij, Femke M.S., Verhoef, Lisette G.G.C., Fischer, David F., van Leeuwen, Fred W., Hol, Elly M., Masucci, Maria G., Dantuma, Nico P.
Publicado em 2002

Localization of mutant ubiquitin in the brain of a transgenic mouse line with proteasomal inhibition and its validation at specific sites in Alzheimer's disease

Por Gentier, Romina J. G., Verheijen, Bert M., Zamboni, Margherita, Stroeken, Maartje M. A., Hermes, Denise J. H. P., Küsters, Benno, Steinbusch, Harry W. M., Hopkins, David A., Van Leeuwen, Fred W.
Publicado no Front Neuroanat (2015)

Expression of progerin in aging mouse brains reveals structural nuclear abnormalities without detectible significant alterations in gene expression, hippocampal stem cells or behav...

Por Baek, Jean-Ha, Schmidt, Eva, Viceconte, Nikenza, Strandgren, Charlotte, Pernold, Karin, Richard, Thibaud J. C., Van Leeuwen, Fred W., Dantuma, Nico P., Damberg, Peter, Hultenby, Kjell, Ulfhake, Brun, Mugnaini, Enrico, Rozell, Björn, Eriksson, Maria
Publicado no Hum Mol Genet (2015)

Accumulation of Basic Amino Acids at Mitochondria Dictates the Cytotoxicity of Aberrant Ubiquitin

Por Braun, Ralf J., Sommer, Cornelia, Leibiger, Christine, Gentier, Romina J.G., Dumit, Verónica I., Paduch, Katrin, Eisenberg, Tobias, Habernig, Lukas, Trausinger, Gert, Magnes, Christoph, Pieber, Thomas, Sinner, Frank, Dengjel, Jörn, van Leeuwen, Fred W., Kroemer, Guido, Madeo, Frank
Publicado no Cell Rep (2015)

Long-term proteasomal inhibition in transgenic mice by UBB(+1) expression results in dysfunction of central respiration control reminiscent of brainstem neuropathology in Alzheimer...

Por Irmler, Martin, Gentier, Romina J. G., Dennissen, Frank J. A., Schulz, Holger, Bolle, Ines, Hölter, Sabine M., Kallnik, Magdalena, Cheng, Jing Jun, Klingenspor, Martin, Rozman, Jan, Ehrhardt, Nicole, Hermes, Denise J. H. P., Gailus-Durner, Valérie, Fuchs, Helmut, Hrabě de Angelis, Martin, Meyer, Helmut E., Hopkins, David A., Van Leeuwen, Fred W., Beckers, Johannes
Publicado em 2012