Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation

Loss of neurons in neurodegenerative diseases is usually preceded by the accumulation of protein deposits that contain components of the ubiquitin/proteasome system. Affected neurons in Alzheimer's disease often accumulate UBB(+1), a mutant ubiquitin carrying a 19–amino acid C-terminal extensio...

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Main Authors: Lindsten, Kristina, de Vrij, Femke M.S., Verhoef, Lisette G.G.C., Fischer, David F., van Leeuwen, Fred W., Hol, Elly M., Masucci, Maria G., Dantuma, Nico P.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2002
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173284/
https://ncbi.nlm.nih.gov/pubmed/11980917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200111034
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