Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer’s disease patients

Epigenetic dysregulation of gene expression is thought to be critically involved in the pathophysiology of Alzheimer’s disease (AD). Recent studies indicate that DNA methylation and DNA hydroxymethylation are 2 important epigenetic mechanisms that regulate gene expression in the aging brain. However...

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Detalhes bibliográficos
Main Authors: Chouliaras, Leonidas, Mastroeni, Diego, Delvaux, Elaine, Grover, Andrew, Kenis, Gunter, Hof, Patrick R., Steinbusch, Harry W.M., Coleman, Paul D., Rutten, Bart P.F., van den Hove, Daniel L.A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3955118/
https://ncbi.nlm.nih.gov/pubmed/23582657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2013.02.021
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