Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer’s disease patients

Epigenetic dysregulation of gene expression is thought to be critically involved in the pathophysiology of Alzheimer’s disease (AD). Recent studies indicate that DNA methylation and DNA hydroxymethylation are 2 important epigenetic mechanisms that regulate gene expression in the aging brain. However...

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Hauptverfasser: Chouliaras, Leonidas, Mastroeni, Diego, Delvaux, Elaine, Grover, Andrew, Kenis, Gunter, Hof, Patrick R., Steinbusch, Harry W.M., Coleman, Paul D., Rutten, Bart P.F., van den Hove, Daniel L.A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3955118/
https://ncbi.nlm.nih.gov/pubmed/23582657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2013.02.021
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