Epigenetic regulation of mitochondrial function in neurodegenerative disease: new insights from advances in genomic technologies

Por Devall, Matthew, Roubroeks, Janou, Mill, Jonathan, Weedon, Michael, Lunnon, Katie
Publicado no Neurosci Lett (2016)

A cautionary tale: the non-causal association between type 2 diabetes risk SNP, rs7756992, and levels of non-coding RNA, CDKAL1-v1

Por Locke, Jonathan M., Wei, Fan-Yan, Tomizawa, Kazuhito, Weedon, Michael N., Harries, Lorna W.
Publicado no Diabetologia (2015)

Cohort profile for the MASTERMIND study: using the Clinical Practice Research Datalink (CPRD) to investigate stratification of response to treatment in patients with type 2 diabete...

Por Rodgers, Lauren R, Weedon, Michael N, Henley, William E, Hattersley, Andrew T, Shields, Beverley M
Publicado no BMJ Open (2017)

Events in Early Life are Associated with Female Reproductive Ageing: A UK Biobank Study

Por Ruth, Katherine S., Perry, John R. B., Henley, William E., Melzer, David, Weedon, Michael N., Murray, Anna
Publicado no Sci Rep (2016)

Length of FMR1 repeat alleles within the normal range does not substantially affect the risk of early menopause

Por Ruth, Katherine S., Bennett, Claire E., Schoemaker, Minouk J., Weedon, Michael N., Swerdlow, Anthony J., Murray, Anna
Publicado no Hum Reprod (2016)

Frequency and phenotype of type 1 diabetes in the first six decades of life: a cross-sectional, genetically stratified survival analysis from UK Biobank

Por Thomas, Nicholas J, Jones, Samuel E, Weedon, Michael N, Shields, Beverley M, Oram, Richard A, Hattersley, Andrew T
Publicado no Lancet Diabetes Endocrinol (2018)

A study of association between common variation in the growth hormone-chorionic somatomammotropin hormone gene cluster and adult fasting insulin in a UK Caucasian population

Por Freathy, Rachel M, Mitchell, Simon MS, Knight, Beatrice, Shields, Beverley, Weedon, Michael N, Hattersley, Andrew T, Frayling, Timothy M
Publicado em 2006

Interrogating Type 2 Diabetes Genome-Wide Association Data Using a Biological Pathway-Based Approach

Por Perry, John R.B., McCarthy, Mark I., Hattersley, Andrew T., Zeggini, Eleftheria, Weedon, Michael N., Frayling, Timothy M.
Publicado em 2009

Regional differences in mitochondrial DNA methylation in human post-mortem brain tissue

Por Devall, Matthew, Smith, Rebecca G., Jeffries, Aaron, Hannon, Eilis, Davies, Matthew N., Schalkwyk, Leonard, Mill, Jonathan, Weedon, Michael, Lunnon, Katie
Publicado no Clin Epigenetics (2017)

A Type 1 diabetes genetic risk score can aid discrimination between Type 1 and Type 2 diabetes in young adults

Por Oram, Richard A, Patel, Kashyap, Hill, Anita, Shields, Beverley, McDonald, Timothy J, Jones, Angus, Hattersley, Andrew T, Weedon, Michael N
Publicado no Diabetes Care (2015)

Next generation sequencing of chromosomal rearrangements in patients with split-hand/split-foot malformation provides evidence for DYNC1I1 exonic enhancers of DLX5/6 expression in...

Por Lango Allen, Hana, Caswell, Richard, Xie, Weijia, Xu, Xiao, Wragg, Christopher, Turnpenny, Peter D, Turner, Claire L S, Weedon, Michael N, Ellard, Sian
Publicado em 2014

Assessing the Combined Impact of 18 Common Genetic Variants of Modest Effect Sizes on Type 2 Diabetes Risk

Por Lango, Hana, Palmer, Colin N.A., Morris, Andrew D., Zeggini, Eleftheria, Hattersley, Andrew T., McCarthy, Mark I., Frayling, Timothy M., Weedon, Michael N.
Publicado em 2008

A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5–CHRNA3–CHRNB4) is associated with a reduced ability of women to quit smoking in pregnanc...

Por Freathy, Rachel M., Ring, Susan M., Shields, Beverley, Galobardes, Bruna, Knight, Beatrice, Weedon, Michael N., Smith, George Davey, Frayling, Timothy M., Hattersley, Andrew T.
Publicado em 2009

Adherence to oral glucose lowering therapies and associations with one year HbA(1c): a retrospective cohort analysis in a large primary care database

Por Farmer, Andrew J., Rodgers, Lauren R, Lonergan, Mike, Shields, Beverley, Weedon, Michael N., Donnelly, Louise, Holman, Rury R., Pearson, Ewan R., Hattersley, Andrew T
Publicado no Diabetes Care (2015)

Effects of the diabetes linked <it>TCF7L2 </it>polymorphism in a representative older population

Por Ferrucci Luigi, Corsi Anna, Bandinelli Stefania, Weedon Michael N, Hurst Alison J, Murray Anna, Melzer David, Paolisso Guiseppe, Guralnik Jack M, Frayling Timothy M
Publicado em 2006-12-01

The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians

Por Freathy, Rachel M, Weedon, Michael N, Melzer, David, Shields, Beverley, Hitman, Graham A, Walker, Mark, McCarthy, Mark I, Hattersley, Andrew T, Frayling, Timothy M
Publicado em 2006

Exome Sequencing Identifies a DYNC1H1 Mutation in a Large Pedigree with Dominant Axonal Charcot-Marie-Tooth Disease

Por Weedon, Michael N., Hastings, Robert, Caswell, Richard, Xie, Weijia, Paszkiewicz, Konrad, Antoniadi, Thalia, Williams, Maggie, King, Cath, Greenhalgh, Lynn, Newbury-Ecob, Ruth, Ellard, Sian
Publicado em 2011

Effects of the diabetes linked TCF7L2 polymorphism in a representative older population

Por Melzer, David, Murray, Anna, Hurst, Alison J, Weedon, Michael N, Bandinelli, Stefania, Corsi, Anna Maria, Ferrucci, Luigi, Paolisso, Guiseppe, Guralnik, Jack M, Frayling, Timothy M
Publicado em 2006

Pitfalls of haplotype phasing from amplicon-based long-read sequencing

Por Laver, Thomas W., Caswell, Richard C., Moore, Karen A., Poschmann, Jeremie, Johnson, Matthew B., Owens, Martina M., Ellard, Sian, Paszkiewicz, Konrad H., Weedon, Michael N.
Publicado no Sci Rep (2016)

Novel homozygous missense mutation in GAN associated with Charcot-Marie-Tooth disease type 2 in a large consanguineous family from Israel

Por Aharoni, Sharon, Barwick, Katy E. S., Straussberg, Rachel, Harlalka, Gaurav V., Nevo, Yoram, Chioza, Barry A., McEntagart, Meriel M., Mimouni-Bloch, Aviva, Weedon, Michael, Crosby, Andrew H.
Publicado no BMC Med Genet (2016)