The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians

BACKGROUND: Klotho has an important role in insulin signalling and the development of ageing-like phenotypes in mice. The common functional "KL-VS" variant in the KLOTHO (KL) gene is associated with longevity in humans but its role in type 2 diabetes is not known. We performed a large case...

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Main Authors: Freathy, Rachel M, Weedon, Michael N, Melzer, David, Shields, Beverley, Hitman, Graham A, Walker, Mark, McCarthy, Mark I, Hattersley, Andrew T, Frayling, Timothy M
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2006
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1534014/
https://ncbi.nlm.nih.gov/pubmed/16753056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2350-7-51
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