A Perspective on Vascular Disrupting Agents that Interact with Tubulin: Preclinical Tumor Imaging and Biological Assessment

Por Mason, Ralph P., Zhao, Dawen, Liu, Li, Trawick, Mary Lynn, Pinney, Kevin G.
Publicado em 2011

Application of the McMurry Coupling Reaction in the Synthesis of Tri- and Tetra-arylethylene Analogues as Potential Cancer Chemotherapeutic Agents

Por Tanpure, Rajendra P., Harkrider, Amanda R., Strecker, Tracy E., Hamel, Ernest, Trawick, Mary Lynn, Pinney, Kevin G.
Publicado em 2009

An Amino-Benzosuberene Analogue That Inhibits Tubulin Assembly and Demonstrates Remarkable Cytotoxicity

Por Tanpure, Rajendra P., George, Clinton S., Sriram, Madhavi, Strecker, Tracy E., Tidmore, Justin K., Hamel, Ernest, Charlton-Sevcik, Amanda K., Chaplin, David J., Trawick, Mary Lynn, Pinney, Kevin G.
Publicado em 2012

Evaluation of tumor ischemia in response to an indole-based vascular disrupting agent using BLI and (19)F MRI

Por Zhou, Heling, Hallac, Rami R, Lopez, Ramona, Denney, Rebecca, MacDonough, Matthew T, Li, Li, Liu, Li, Graves, Edward E, Trawick, Mary Lynn, Pinney, Kevin G, Mason, Ralph P
Publicado no Am J Nucl Med Mol Imaging (2015)

Synthesis and Biological Evaluation of Benzocyclooctene-based and Indene-based Anticancer Agents that Function as Inhibitors of Tubulin Polymerization()

Por Herdman, Christine A., Strecker, Tracy E., Tanpure, Rajendra P., Chen, Zhi, Winters, Alex, Gerberich, Jeni, Liu, Li, Hamel, Ernest, Mason, Ralph P., Chaplin, David J., Trawick, Mary Lynn, Pinney, Kevin G.
Publicado no Medchemcomm (2016)

Synthesis and Biochemical Evaluation of Thiochromanone Thiosemicarbazone Analogues as Inhibitors of Cathepsin L

Por Song, Jiangli, Jones, Lindsay M., Kumar, G. D. Kishore, Conner, Elizabeth S., Bayeh, Liela, Chavarria, Gustavo E., Charlton-Sevcik, Amanda K., Chen, Shen-En, Chaplin, David J., Trawick, Mary Lynn, Pinney, Kevin G.
Publicado em 2012

Regioselective Synthesis of Water Soluble Monophosphate Derivatives of Combretastatin A-1

Por Tanpure, Rajendra P., Nguyen, Benson L., Strecker, Tracy E., Aguirre, Savannah, Sharma, Suman, Chaplin, David J., Siim, Bronwyn G., Hamel, Ernest, Lippert, John W., Pettit, George R., Trawick, Mary Lynn, Pinney, Kevin G.
Publicado em 2011

Synthesis of structurally diverse benzosuberene analogues and their biological evaluation as anti-cancer agents

Por Tanpure, Rajendra P., George, Clinton S., Strecker, Tracy E., Devkota, Laxman, Tidmore, Justin K., Lin, Chen-Ming, Herdman, Christine A., MacDonough, Matthew T., Sriram, Madhavi, Chaplin, David J., Trawick, Mary Lynn, Pinney, Kevin G.
Publicado em 2013

Structural Interrogation of Benzosuberene-Based Inhibitors of Tubulin Polymerization

Por Herdman, Christine A., Devkota, Laxman, Lin, Chen-Ming, Niu, Haichan, Strecker, Tracy E., Lopez, Ramona, Liu, Li, George, Clinton S., Tanpure, Rajendra P., Hamel, Ernest, Chaplin, David J., Mason, Ralph P., Trawick, Mary Lynn, Pinney, Kevin G.
Publicado no Bioorg Med Chem (2015)

Design, Synthesis, and Biological Evaluation of Water-Soluble Amino Acid Prodrug Conjugates Derived from Combretastatin, Dihydronaphthalene, and Benzosuberene-Based Parent Vascular...

Por Devkota, Laxman, Lin, Chen-Ming, Strecker, Tracy E., Wang, Yifan, Tidmore, Justin K., Chen, Zhi, Guddneppanavar, Rajsekhar, Jelinek, Christopher J., Lopez, Ramona, Liu, Li, Hamel, Ernest, Mason, Ralph P., Chaplin, David J., Trawick, Mary Lynn, Pinney, Kevin G.
Publicado no Bioorg Med Chem (2016)

The Vascular Disrupting Activity of OXi8006 in Endothelial Cells and Its Phosphate Prodrug OXi8007 in Breast Tumor Xenografts

Por Strecker, Tracy E., Odutola, Samuel O., Lopez, Ramona, Cooper, Morgan S., Tidmore, Justin K., Charlton-Sevcik, Amanda K., Li, Li, MacDonough, Matthew T., Hadimani, Mallinath B., Ghatak, Anjan, Liu, Li, Chaplin, David J., Mason, Ralph P., Pinney, Kevin G., Trawick, Mary Lynn
Publicado no Cancer Lett (2015)

Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L

Por Parker, Erica N., Song, Jiangli, Kumar, G. D. Kishore, Odutola, Samuel O., Chavarria, Gustavo E., Charlton-Sevcik, Amanda K., Strecker, Tracy E., Barnes, Ashleigh L., Sudhan, Dhivya R., Wittenborn, Thomas R., Siemann, Dietmar W., Horsman, Michael R., Chaplin, David J., Trawick, Mary Lynn, Pinney, Kevin G.
Publicado no Bioorg Med Chem (2015)

Synthesis of a 2-Aryl-3-Aroyl-Indole Salt (OXi8007) Resembling Combretastatin A-4 with Application as a Vascular Disrupting Agent

Por Hadimani, Mallinath B., MacDonough, Matthew T., Ghatak, Anjan, Strecker, Tracy E., Lopez, Ramona, Sriram, Madhavi, Nguyen, Benson L., Hall, John J., Kessler, Raymond J., Shirali, Anupama R., Liu, Li, Garner, Charles M., Pettit, George R., Hamel, Ernest, Chaplin, David J., Mason, Ralph P., Trawick, Mary Lynn, Pinney, Kevin G.
Publicado em 2013