Bioreductively Activatable Prodrug Conjugates of Combretastatin A-1 and Combretastatin A-4 as Anticancer Agents Targeted Towards Tumor-Associated Hypoxia

The natural products combretastatin A-1 (CA1) and combretastatin A-4 (CA4) function as potent inhibitors of tubulin polymerization and as selective vascular disrupting agents (VDAs) in tumors. Bioreductively activatable prodrug conjugates (BAPCs) can enhance selectivity by serving as substrates for...

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Publicado no:J Nat Prod
Main Authors: Winn, Blake A., Devkota, Laxman, Kuch, Bunnarack, MacDonough, Matthew T., Strecker, Tracy E., Wang, Yifan, Shi, Zhe, Gerberich, Jeni L., Mondal, Deboprosad, Ramirez, Alejandro J., Hamel, Ernest, Chaplin, David J., Davis, Peter, Mason, Ralph P., Trawick, Mary Lynn, Pinney, Kevin G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7644341/
https://ncbi.nlm.nih.gov/pubmed/32196334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jnatprod.9b00773
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