Bioreductively Activatable Prodrug Conjugates of Combretastatin A-1 and Combretastatin A-4 as Anticancer Agents Targeted Towards Tumor-Associated Hypoxia

The natural products combretastatin A-1 (CA1) and combretastatin A-4 (CA4) function as potent inhibitors of tubulin polymerization and as selective vascular disrupting agents (VDAs) in tumors. Bioreductively activatable prodrug conjugates (BAPCs) can enhance selectivity by serving as substrates for...

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Publicado en:J Nat Prod
Autores principales: Winn, Blake A., Devkota, Laxman, Kuch, Bunnarack, MacDonough, Matthew T., Strecker, Tracy E., Wang, Yifan, Shi, Zhe, Gerberich, Jeni L., Mondal, Deboprosad, Ramirez, Alejandro J., Hamel, Ernest, Chaplin, David J., Davis, Peter, Mason, Ralph P., Trawick, Mary Lynn, Pinney, Kevin G.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7644341/
https://ncbi.nlm.nih.gov/pubmed/32196334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jnatprod.9b00773
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