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Bioreductively Activatable Prodrug Conjugates of Combretastatin A-1 and Combretastatin A-4 as Anticancer Agents Targeted Towards Tumor-Associated Hypoxia

The natural products combretastatin A-1 (CA1) and combretastatin A-4 (CA4) function as potent inhibitors of tubulin polymerization and as selective vascular disrupting agents (VDAs) in tumors. Bioreductively activatable prodrug conjugates (BAPCs) can enhance selectivity by serving as substrates for...

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Dades bibliogràfiques
Publicat a:J Nat Prod
Autors principals: Winn, Blake A., Devkota, Laxman, Kuch, Bunnarack, MacDonough, Matthew T., Strecker, Tracy E., Wang, Yifan, Shi, Zhe, Gerberich, Jeni L., Mondal, Deboprosad, Ramirez, Alejandro J., Hamel, Ernest, Chaplin, David J., Davis, Peter, Mason, Ralph P., Trawick, Mary Lynn, Pinney, Kevin G.
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7644341/
https://ncbi.nlm.nih.gov/pubmed/32196334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jnatprod.9b00773
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