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Design, Synthesis, and Biological Evaluation of Water-Soluble Amino Acid Prodrug Conjugates Derived from Combretastatin, Dihydronaphthalene, and Benzosuberene-Based Parent Vascular Disrupting Agents

Targeting tumor vasculature represents an intriguing therapeutic strategy in the treatment of cancer. In an effort to discover new vascular disrupting agents with improved water solubility and potentially greater bioavailability, various amino acid prodrug conjugates (AAPCs) of potent amino combreta...

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Bibliografiske detaljer
Udgivet i:Bioorg Med Chem
Main Authors: Devkota, Laxman, Lin, Chen-Ming, Strecker, Tracy E., Wang, Yifan, Tidmore, Justin K., Chen, Zhi, Guddneppanavar, Rajsekhar, Jelinek, Christopher J., Lopez, Ramona, Liu, Li, Hamel, Ernest, Mason, Ralph P., Chaplin, David J., Trawick, Mary Lynn, Pinney, Kevin G.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4846294/
https://ncbi.nlm.nih.gov/pubmed/26852340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.01.007
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