An Amino-Benzosuberene Analogue That Inhibits Tubulin Assembly and Demonstrates Remarkable Cytotoxicity

The recent discovery of a small-molecule benzosuberene-based phenol that demonstrates remarkable picomolar cytotoxicity against selected human cancer cell lines and strongly inhibits tubulin polymerization (1–2 µM) inspired the design and synthesis of a variety of new, structurally diverse benzosube...

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Bibliographische Detailangaben
Hauptverfasser: Tanpure, Rajendra P., George, Clinton S., Sriram, Madhavi, Strecker, Tracy E., Tidmore, Justin K., Hamel, Ernest, Charlton-Sevcik, Amanda K., Chaplin, David J., Trawick, Mary Lynn, Pinney, Kevin G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682772/
https://ncbi.nlm.nih.gov/pubmed/23772309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C2MD00318J
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