Regioselective Synthesis of Water Soluble Monophosphate Derivatives of Combretastatin A-1

The natural products combretastatin A-4 (CA4) and combretastatin A-1 (CA1) are potent cancer vascular disrupting agents (VDAs) and inhibitors of tubulin assembly (IC(50) = 1–2 μM). The phosphorylated prodrugs CA4P and CA1P are undergoing human clinical trials against cancer. CA1 is unique due to its...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Tanpure, Rajendra P., Nguyen, Benson L., Strecker, Tracy E., Aguirre, Savannah, Sharma, Suman, Chaplin, David J., Siim, Bronwyn G., Hamel, Ernest, Lippert, John W., Pettit, George R., Trawick, Mary Lynn, Pinney, Kevin G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3275140/
https://ncbi.nlm.nih.gov/pubmed/21718055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np200104t
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados