Regioselective Synthesis of Water Soluble Monophosphate Derivatives of Combretastatin A-1

The natural products combretastatin A-4 (CA4) and combretastatin A-1 (CA1) are potent cancer vascular disrupting agents (VDAs) and inhibitors of tubulin assembly (IC(50) = 1–2 μM). The phosphorylated prodrugs CA4P and CA1P are undergoing human clinical trials against cancer. CA1 is unique due to its...

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Detaylı Bibliyografya
Asıl Yazarlar: Tanpure, Rajendra P., Nguyen, Benson L., Strecker, Tracy E., Aguirre, Savannah, Sharma, Suman, Chaplin, David J., Siim, Bronwyn G., Hamel, Ernest, Lippert, John W., Pettit, George R., Trawick, Mary Lynn, Pinney, Kevin G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2011
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3275140/
https://ncbi.nlm.nih.gov/pubmed/21718055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np200104t
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