Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors

A small library of 36 functionalized benzophenone thiosemicarbazone analogs has been prepared by chemical synthesis and evaluated for their ability to inhibit the cysteine proteases cathepsin L and cathepsin B. Inhibitors of cathepsins L and B have the potential to limit or arrest cancer metastasis....

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Kishore Kumar, G.D., Chavarria, Gustavo E., Charlton-Sevcik, Amanda K., Arispe, Wara M., MacDonough, Matthew T., Strecker, Tracy E., Chen, Shen-En, Siim, Bronwyn G., Chaplin, David J., Trawick, Mary Lynn, Pinney, Kevin G.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Ltd. 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7125537/
https://ncbi.nlm.nih.gov/pubmed/20089402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.12.090
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