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Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors
A small library of 36 functionalized benzophenone thiosemicarbazone analogs has been prepared by chemical synthesis and evaluated for their ability to inhibit the cysteine proteases cathepsin L and cathepsin B. Inhibitors of cathepsins L and B have the potential to limit or arrest cancer metastasis....
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| Publicat a: | Bioorg Med Chem Lett |
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| Autors principals: | , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Elsevier Ltd.
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7125537/ https://ncbi.nlm.nih.gov/pubmed/20089402 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.12.090 |
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