Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L

Upregulation of cathepsin L in a variety of tumors and its ability to promote cancer cell invasion and migration through degradation of the extracellular matrix suggest that cathepsin L is a promising biological target for the development of anti-metastatic agents. Based on encouraging results from...

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Publicado no:Bioorg Med Chem
Main Authors: Parker, Erica N., Song, Jiangli, Kumar, G. D. Kishore, Odutola, Samuel O., Chavarria, Gustavo E., Charlton-Sevcik, Amanda K., Strecker, Tracy E., Barnes, Ashleigh L., Sudhan, Dhivya R., Wittenborn, Thomas R., Siemann, Dietmar W., Horsman, Michael R., Chaplin, David J., Trawick, Mary Lynn, Pinney, Kevin G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824049/
https://ncbi.nlm.nih.gov/pubmed/26462052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.09.036
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