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Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L

Upregulation of cathepsin L in a variety of tumors and its ability to promote cancer cell invasion and migration through degradation of the extracellular matrix suggest that cathepsin L is a promising biological target for the development of anti-metastatic agents. Based on encouraging results from...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Bioorg Med Chem
Asıl Yazarlar: Parker, Erica N., Song, Jiangli, Kumar, G. D. Kishore, Odutola, Samuel O., Chavarria, Gustavo E., Charlton-Sevcik, Amanda K., Strecker, Tracy E., Barnes, Ashleigh L., Sudhan, Dhivya R., Wittenborn, Thomas R., Siemann, Dietmar W., Horsman, Michael R., Chaplin, David J., Trawick, Mary Lynn, Pinney, Kevin G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824049/
https://ncbi.nlm.nih.gov/pubmed/26462052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.09.036
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