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Synthesis and biological evaluation of structurally diverse α-conformationally restricted chalcones and related analogues

Numerous members of the combretastatin and chalcone families of natural products function as inhibitors of tubulin polymerization through a binding interaction at the colchicine site on β-tubulin. These molecular scaffolds inspired the development of many structurally modified derivatives and analog...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Medchemcomm
Prif Awduron: Maguire, Casey J., Carlson, Graham J., Ford, Jacob W., Strecker, Tracy E., Hamel, Ernest, Trawick, Mary Lynn, Pinney, Kevin G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Royal Society of Chemistry 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6734540/
https://ncbi.nlm.nih.gov/pubmed/31534659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00127a
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