Synthesis of a 2-Aryl-3-Aroyl-Indole Salt (OXi8007) Resembling Combretastatin A-4 with Application as a Vascular Disrupting Agent

The natural products colchicine and combretastatin A-4 (CA4) are potent inhibitors of tubulin assembly, and they have inspired the design and synthesis of a large number of small-molecule, potential anticancer agents. The indole-based molecular scaffold is prominent among these SAR modifications, le...

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Auteurs principaux: Hadimani, Mallinath B., MacDonough, Matthew T., Ghatak, Anjan, Strecker, Tracy E., Lopez, Ramona, Sriram, Madhavi, Nguyen, Benson L., Hall, John J., Kessler, Raymond J., Shirali, Anupama R., Liu, Li, Garner, Charles M., Pettit, George R., Hamel, Ernest, Chaplin, David J., Mason, Ralph P., Trawick, Mary Lynn, Pinney, Kevin G.
Format: Artigo
Langue:Inglês
Publié: 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985392/
https://ncbi.nlm.nih.gov/pubmed/24016002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np400374w
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