Discovery of a Structurally Unique Small Molecule that Inhibits Protein Synthesis

Por Thakral, Durga, Tae, Hyun Seop
Publicado no Yale J Biol Med (2017)

Unexpected Stereochemical Tolerance for the Biological Activity of Tyroscherin

Por Tae, Hyun Seop, Hines, John, Schneekloth, Ashley R., Crews, Craig M.
Publicado em 2011

Targeted Intracellular Protein Degradation Induced by a Small Molecule: En Route to Chemical Proteomics

Por Smith, Ashley R., Pucheault, Mathieu, Tae, Hyun Seop, Crews, Craig M.
Publicado em 2008

Total Synthesis and Biological Evaluation of Tyroscherin

Por Tae, Hyun Seop, Hines, John, Schneekloth, Ashley R., Crews, Craig M.
Publicado em 2010

Gene selective mRNA cleavage inhibits the development of Plasmodium falciparum

Por Augagneur, Yoann, Wesolowski, Donna, Tae, Hyun Seop, Altman, Sidney, Ben Mamoun, Choukri
Publicado em 2012

Basic peptide-morpholino oligomer conjugate that is very effective in killing bacteria by gene-specific and nonspecific modes

Por Wesolowski, Donna, Tae, Hyun Seop, Gandotra, Neeru, Llopis, Paula, Shen, Ning, Altman, Sidney
Publicado em 2011

A HaloTag-Based Small Molecule Microarray Screening Methodology with Increased Sensitivity and Multiplex Capabilities

Por Noblin, Devin J., Page, Charlotte M., Tae, Hyun Seop, Gareiss, Peter C., Schneekloth, John S., Crews, Craig M.
Publicado em 2012

Identification of Hydrophobic Tags for the Degradation of Stabilized Proteins

Por Tae, Hyun Seop, Sundberg, Thomas B., Neklesa, Taavi K., Noblin, Devin J., Gustafson, Jeffrey L., Roth, Anke G., Raina, Kanak, Crews, Craig M.
Publicado em 2012

Targeting the von Hippel–Lindau E3 Ubiquitin Ligase Using Small Molecules To Disrupt the VHL/HIF-1α Interaction

Por Buckley, Dennis L., Van Molle, Inge, Gareiss, Peter C., Tae, Hyun Seop, Michel, Julien, Noblin, Devin J., Jorgensen, William L., Ciulli, Alessio, Crews, Craig M.
Publicado em 2012

Small-Molecule Hydrophobic Tagging Induced Degradation of HaloTag Fusion Proteins

Por Neklesa, Taavi K., Tae, Hyun Seop, Schneekloth, Ashley R., Stulberg, Michael J., Corson, Timothy W., Sundberg, Thomas B., Raina, Kanak, Holley, Scott A., Crews, Craig M.
Publicado em 2011

Small Molecule Inhibitors of the Interaction Between the E3 Ligase VHL and HIF1α

Por Buckley, Dennis L., Gustafson, Jeffrey L., Van Molle, Inge, Roth, Anke G., Tae, Hyun Seop, Gareiss, Peter C., Jorgensen, William L., Ciulli, Alessio, Crews, Craig M.
Publicado em 2012

Development of small molecules targeting the pseudokinase Her3

Por Lim, Sang Min, Xie, Ting, Westover, Kenneth D., Ficarro, Scott B., Tae, Hyun Seop, Gurbani, Deepak, Sim, Taebo, Marto, Jarrod A., Jänne, Pasi A., Crews, Craig M., Gray, Nathanael S.
Publicado no Bioorg Med Chem Lett (2015)

Small Molecule Mediated Degradation of the Androgen Receptor Through Hydrophobic Tagging

Por Gustafson, Jeffrey L., Neklesa, Taavi K., Cox, Carly S., Roth, Anke G., Buckley, Dennis L., Tae, Hyun Seop, Sundberg, Thomas B., Stagg, D. Blake, Hines, John, McDonnell, Donald P., Norris, John D., Crews, Craig M.
Publicado no Angew Chem Int Ed Engl (2015)

Pharmacological Targeting of the Pseudokinase Her3

Por Xie, Ting, Lim, Sang Min, Westover, Kenneth D., Dodge, Michael E., Ercan, Dalia, Ficarro, Scott B., Udayakumar, Durga, Gurbani, Deepak, Tae, Hyun Seop, Riddle, Steven M., Sim, Taebo, Marto, Jarrod A., Jänne, Pasi A., Crews, Craig M., Gray, Nathanael S.
Publicado no Nat Chem Biol (2014)