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Small Molecule Inhibitors of the Interaction Between the E3 Ligase VHL and HIF1α
E3 ubiquitin ligases, such as the therapeutically relevant VHL, are challenging targets for traditional medicinal chemistry, as their modulation requires targeting protein-protein interactions. We report novel small-molecule inhibitors of the interaction between VHL and its molecular target HIF1α, a...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3519281/ https://ncbi.nlm.nih.gov/pubmed/23065727 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201206231 |
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