Development of small molecules targeting the pseudokinase Her3

Her3 is a member of the human epidermal growth factor receptor (EGFR) tyrosine kinase family, and it is often either overexpressed or deregulated in many types of human cancer. Her3 has not been the subject of small-molecule inhibitor development because it is a pseudokinase and does not possess app...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Lim, Sang Min, Xie, Ting, Westover, Kenneth D., Ficarro, Scott B., Tae, Hyun Seop, Gurbani, Deepak, Sim, Taebo, Marto, Jarrod A., Jänne, Pasi A., Crews, Craig M., Gray, Nathanael S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4633287/
https://ncbi.nlm.nih.gov/pubmed/26094118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.04.103
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