Pharmacological Targeting of the Pseudokinase Her3

Her3 (ErbB3) belongs to the epidermal growth factor receptor tyrosine kinases and is well credentialed as an anti-cancer target but is thought to be “undruggable” using ATP-competitive small molecules because it lacks significant kinase activity. Here we report the first selective Her3 ligand, TX1-8...

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Publicado no:Nat Chem Biol
Main Authors: Xie, Ting, Lim, Sang Min, Westover, Kenneth D., Dodge, Michael E., Ercan, Dalia, Ficarro, Scott B., Udayakumar, Durga, Gurbani, Deepak, Tae, Hyun Seop, Riddle, Steven M., Sim, Taebo, Marto, Jarrod A., Jänne, Pasi A., Crews, Craig M., Gray, Nathanael S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4232461/
https://ncbi.nlm.nih.gov/pubmed/25326665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1658
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