Pharmacological Targeting of the Pseudokinase Her3

Her3 (ErbB3) belongs to the epidermal growth factor receptor tyrosine kinases and is well credentialed as an anti-cancer target but is thought to be “undruggable” using ATP-competitive small molecules because it lacks significant kinase activity. Here we report the first selective Her3 ligand, TX1-8...

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Publicat a:Nat Chem Biol
Autors principals: Xie, Ting, Lim, Sang Min, Westover, Kenneth D., Dodge, Michael E., Ercan, Dalia, Ficarro, Scott B., Udayakumar, Durga, Gurbani, Deepak, Tae, Hyun Seop, Riddle, Steven M., Sim, Taebo, Marto, Jarrod A., Jänne, Pasi A., Crews, Craig M., Gray, Nathanael S.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4232461/
https://ncbi.nlm.nih.gov/pubmed/25326665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1658
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