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Discovery of selective irreversible inhibitors for EGFR-T790M

Targeting the epidermal growth factor receptor kinase (EGFR) with ATP-competitive kinase inhibitors results in dramatic but short-lived responses in patients with EGFR mutant non small cell lung cancer. A series of novel covalent EGFR kinase inhibitors with selectivity for the clinically relevant T7...

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Bibliografiska uppgifter
Huvudupphovsmän: Zhou, Wenjun, Ercan, Dalia, Jänne, Pasi A., Gray, Nathanael S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035422/
https://ncbi.nlm.nih.gov/pubmed/21208802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.12.036
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