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Discovery of selective irreversible inhibitors for EGFR-T790M
Targeting the epidermal growth factor receptor kinase (EGFR) with ATP-competitive kinase inhibitors results in dramatic but short-lived responses in patients with EGFR mutant non small cell lung cancer. A series of novel covalent EGFR kinase inhibitors with selectivity for the clinically relevant T7...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3035422/ https://ncbi.nlm.nih.gov/pubmed/21208802 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.12.036 |
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