Structural and Biochemical Analyses Reveal the Mechanism of Glutathione S-Transferase Pi 1 Inhibition by the Anti-cancer Compound Piperlongumine

Glutathione S-transferase pi 1 (GSTP1) is frequently overexpressed in cancerous tumors and is a putative target of the plant compound piperlongumine (PL), which contains two reactive olefins and inhibits proliferation in cancer cells but not normal cells. PL exposure of cancer cells results in incre...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Harshbarger, Wayne, Gondi, Sudershan, Ficarro, Scott B., Hunter, John, Udayakumar, Durga, Gurbani, Deepak, Singer, William D., Liu, Yan, Li, Lianbo, Marto, Jarrod A., Westover, Kenneth D.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2017
Sujets:
Protein Structure and Folding
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5217671/
https://ncbi.nlm.nih.gov/pubmed/27872191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.750299
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