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Unexpected Stereochemical Tolerance for the Biological Activity of Tyroscherin
Here we describe the concise syntheses of the 15 diastereomers and key analogs of the natural product tyroscherin. While systematic analysis of the analogs clearly demonstrated that the hydrocarbon tail is important for biological activity, structure-activity relationship studies of the complete tyr...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3056444/ https://ncbi.nlm.nih.gov/pubmed/21315614 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.01.027 |
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