Unexpected Stereochemical Tolerance for the Biological Activity of Tyroscherin

Here we describe the concise syntheses of the 15 diastereomers and key analogs of the natural product tyroscherin. While systematic analysis of the analogs clearly demonstrated that the hydrocarbon tail is important for biological activity, structure-activity relationship studies of the complete tyr...

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Detaylı Bibliyografya
Asıl Yazarlar: Tae, Hyun Seop, Hines, John, Schneekloth, Ashley R., Crews, Craig M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2011
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3056444/
https://ncbi.nlm.nih.gov/pubmed/21315614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.01.027
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